PRPF38B

Across TCGA patient cohorts, PRPF38B mutation is significantly associated with the RNA expression of many other genes, with 2,867 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF38B-associated genes across cancer lineages are NKG7, MED31, and WRAP53. Each is linked with PRPF38B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF38B-to-partner and partner-to-PRPF38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKG7 grouped by PRPF38B-low versus PRPF38B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38B→partner) and Y-score (partner→PRPF38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NKG7 →	+0.870	+3.247	.001	<.001	3	2
UCEC	MED31 →	+0.518	+2.568	<.001	<.001	3	2
UCEC	WRAP53 →	+0.367	+1.968	.002	<.001	3	2
UCEC	GZMA →	+0.692	+1.711	.008	.001	3	2
UCEC	JAKMIP1 →	+0.519	+4.021	<.001	<.001	3	2
UCEC	SKA1 →	+0.559	+2.928	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,867 associations by consensus.

NKG7 by PRPF38B expression — UCEC

Explore this box plot interactively →