PRPF38B

Across TCGA pan-cancer cohorts, PRPF38B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRPF38B’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where PRPF38B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRPF38B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

STAD, THCA, and LIHC are the cancer types where PRPF38B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPF38B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.822	<.001	10	view →
THCA	All	II,III,IV	−0.590	<.001	10	view →
LIHC	All	II,III,IV	+0.710	<.001	8	view →
HNSC	Male	All	+0.522	<.001	8	view →
KIRC	All	All	+0.382	<.001	8	view →
CHOL	Male	All	+2.186	<.001	5	view →
KICH	Female	All	−1.096	<.001	5	view →
COAD	All	II,III,IV	+0.518	.001	4	view →
BLCA	All	III,IV	+0.407	.013	2	view →
ESCA	All	All	+0.548	.049	1	view →
READ	All	All	+0.480	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRPF38B–STAD

Open the STAD breakdown →