PRPF38B

Across TCGA patient cohorts, PRPF38B mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF38B-associated genes across cancer lineages are eEF2, A-Raf_pS299, and 14-3-3_beta. Each is linked with PRPF38B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF38B-to-partner and partner-to-PRPF38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PRPF38B-low versus PRPF38B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38B→partner) and Y-score (partner→PRPF38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.246	+2.000	.034	.029	3	2
UCEC	A-Raf_pS299 →	-0.098	-1.807	.011	.024	3	2
UCEC	14-3-3_beta →	-0.098	-3.880	.002	<.001	3	1
UCEC	Fibronectin →	-0.248	-1.838	.020	.007	3	1
UCEC	FoxM1 →	+0.200	+2.321	.017	<.001	3	1
UCEC	GATA6 →	-0.146	-2.307	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

eEF2 by PRPF38B expression — UCEC

Explore this box plot interactively →