PRPF38B

Across TCGA cell cohorts, PRPF38B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,802 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPF38B-associated GO terms across cancer lineages are Positive regulation of nuclear cell cycle DNA replication, mRNA 5'-splice site recognition, and Double-strand break repair. Each is linked with PRPF38B in more than 15 cancer types. Because this analysis shows association rather than direction, both PRPF38B-to-partner and partner-to-PRPF38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear cell cycle DNA replication grouped by PRPF38B-low versus PRPF38B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38B→partner) and Y-score (partner→PRPF38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of nuclear cell cycle DNA replication →	+0.191	+1.085	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	mRNA 5'-splice site recognition →	+0.147	+1.105	<.001	<.001	3	16
BONE	Double-strand break repair →	+0.099	+0.996	.001	.001	3	16
BONE	DNA recombination →	+0.080	+0.856	.005	<.001	3	16
BONE	Subtelomeric heterochromatin formation →	+0.153	+0.803	<.001	.008	3	15
BONE	Telomere organization →	+0.100	+1.061	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,802 associations by consensus.

Positive regulation of nuclear cell cycle DNA replication by PRPF38B expression — BONE

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