PRPF38B

Across TCGA cell cohorts, PRPF38B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF38B-associated genes across cancer lineages are OR5AU1, LCE5A, and CMA1. Each is linked with PRPF38B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF38B-to-partner and partner-to-PRPF38B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by PRPF38B-low versus PRPF38B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF38B→partner) and Y-score (partner→PRPF38B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR5AU1 →	+0.031	+4.882	<.001	.001	3	1
SOFT_TISSUE	LCE5A →	+0.756	+4.635	<.001	.003	3	1
SOFT_TISSUE	CMA1 →	+0.156	+4.417	<.001	.004	3	1
LARGE_INTESTINE	CDH20 →	+0.147	+3.766	<.001	.004	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR1F1 →	+0.276	+3.658	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR5AU1 by PRPF38B expression — SOFT_TISSUE

Explore this box plot interactively →