PRPF19

Across TCGA patient cohorts, PRPF19 mutation is significantly associated with the RNA expression of many other genes, with 960 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF19-associated genes across cancer lineages are RNY3P7, RNU6-223P, and SNORD116-3. Each is linked with PRPF19 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF19-to-partner and partner-to-PRPF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P7 grouped by PRPF19-low versus PRPF19-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF19→partner) and Y-score (partner→PRPF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNY3P7 →	+0.478	+4.150	<.001	.003	3	3
BLCA	RNU6-223P →	+0.192	+4.147	.007	.009	3	2
LUAD	SNORD116-3 →	+0.598	+4.962	<.001	.002	3	2
LUAD	MTCO1P5 →	+0.120	+6.599	<.001	<.001	3	2
UCEC	RNA5SP389 →	+0.557	+2.353	<.001	.004	3	2
UCEC	RNU6-863P →	+0.254	+2.162	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 960 associations by consensus.

RNY3P7 by PRPF19 expression — LUSC

Explore this box plot interactively →