PRPF18

Across TCGA patient cohorts, PRPF18 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF18-associated genes across cancer lineages are JNK2, MEK1, and MSH2. Each is linked with PRPF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF18-to-partner and partner-to-PRPF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PRPF18-low versus PRPF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF18→partner) and Y-score (partner→PRPF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.203	+2.502	.009	.002	3	1
UCEC	MEK1 →	+0.452	+3.700	.001	.001	3	1
UCEC	MSH2 →	-0.253	-1.848	.005	.049	3	1
UCEC	PDCD4 →	-0.392	-2.000	.034	.010	3	1
UCEC	BRCA2 →	-0.162	-1.800	.002	.027	3	1
UCEC	Chk2_pT68 →	-0.168	-3.143	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by PRPF18 expression — UCEC

Explore this box plot interactively →