PROZ

Across TCGA patient cohorts, PROZ mutation is significantly associated with the RNA expression of many other genes, with 1,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROZ-associated genes across cancer lineages are GOLGA6L11P, RNU6-648P, and RNA5SP35. Each is linked with PROZ in more than 2 cancer types. Because this analysis shows association rather than direction, both PROZ-to-partner and partner-to-PROZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L11P grouped by PROZ-low versus PROZ-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROZ→partner) and Y-score (partner→PROZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GOLGA6L11P →	+0.052	+5.411	<.001	.005	3	3
BRCA	RNU6-648P →	+0.202	+8.055	<.001	.007	3	2
UCEC	RNA5SP35 →	+0.177	+2.211	.004	.007	3	2
COAD	PINCR →	+0.321	+3.120	<.001	.007	3	2
UCEC	LINC01072 →	+0.148	+2.788	<.001	<.001	3	2
UCEC	MIR3193 →	+0.437	+1.838	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,149 associations by consensus.

GOLGA6L11P by PROZ expression — BLCA

Explore this box plot interactively →