PROX2

Across TCGA cell cohorts, PROX2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROX2-associated genes across cancer lineages are AKAIN1, CD180, and MMP26. Each is linked with PROX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROX2-to-partner and partner-to-PROX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKAIN1 grouped by PROX2-low versus PROX2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX2→partner) and Y-score (partner→PROX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AKAIN1 →	+0.095	+4.930	<.001	.001	3	1
LARGE_INTESTINE	CD180 →	+0.101	+3.736	<.001	.004	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1
LARGE_INTESTINE	OR5V1 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CNNM1 →	+1.003	+3.554	.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

AKAIN1 by PROX2 expression — SKIN

Explore this box plot interactively →