PROX1

Across TCGA patient cohorts, PROX1 mutation is significantly associated with the RNA expression of many other genes, with 3,988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROX1-associated genes across cancer lineages are CD207, SCN4B, and UBE2T. Each is linked with PROX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PROX1-to-partner and partner-to-PROX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD207 grouped by PROX1-low versus PROX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX1→partner) and Y-score (partner→PROX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD207 →	-0.755	-1.736	<.001	<.001	3	5
UCEC	SCN4B →	-0.334	-2.076	.003	.005	3	4
UCEC	UBE2T →	+0.517	+1.779	.001	<.001	3	4
UCEC	TRMU →	+0.333	+1.652	<.001	.005	3	4
UCEC	CMC2 →	+0.449	+1.954	<.001	<.001	3	4
STAD	FCER1A →	-1.029	-3.442	.007	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

CD207 by PROX1 expression — UCEC

Explore this box plot interactively →