PROX1

Across TCGA pan-cancer cohorts, PROX1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PROX1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PROX1 RNA is repressed in tumor relative to normal tissue. In most cancer types PROX1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where PROX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.974	<.001	11	view →
THCA	Male	III,IV	−2.645	<.001	11	view →
KIRP	Male	III,IV	−2.261	<.001	11	view →
COAD	Male	All	+1.420	<.001	10	view →
KICH	Male	All	−3.222	<.001	8	view →
UCEC	All	II,III,IV	−1.374	<.001	8	view →
BRCA	All	III,IV	−1.709	<.001	6	view →
BLCA	Male	All	−1.371	<.001	6	view →
STAD	Male	All	+1.202	<.001	5	view →
READ	All	All	+1.711	.012	2	view →
HNSC	All	III,IV	+0.475	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PROX1–KIRC

Open the KIRC breakdown →