PROX1

Across TCGA patient cohorts, PROX1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROX1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and INPP4B. Each is linked with PROX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROX1-to-partner and partner-to-PROX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PROX1-low versus PROX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX1→partner) and Y-score (partner→PROX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.978	+2.186	.002	.032	3	3
STAD	FoxM1 →	+0.259	+3.169	.045	.019	3	3
UCEC	INPP4B →	-0.248	-2.321	.016	.005	3	3
UCEC	Tuberin →	+0.253	+1.289	.003	.023	3	3
COAD	ATM →	-0.496	-2.459	.001	.018	3	3
COAD	ACVRL1 →	-0.201	-3.157	.047	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by PROX1 expression — COAD

Explore this box plot interactively →