PROX1

Across TCGA cell cohorts, PROX1 RNA expression is significantly associated with the RNA expression of many other genes, with 8,237 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PROX1-associated genes across cancer lineages are HES6, KCNH2, and FOXA2. Each is linked with PROX1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PROX1-to-partner and partner-to-PROX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PROX1 versus HES6 in LUNG_SCLC, with a Pearson correlation of 0.71.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX1→partner) and Y-score (partner→PROX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HES6 →	+3.327	+3.039	<.001	<.001	3	7
BLOOD_Leukemia	KCNH2 →	+1.865	+0.306	<.001	<.001	3	7
LIVER	FOXA2 →	+3.074	+2.691	<.001	<.001	3	6
BONE	EPB41 →	+1.978	+1.532	.002	.001	2	7
LUNG_SCLC	TOX3 →	+3.196	+2.865	<.001	.001	2	7
BONE	SHF →	+2.127	+1.711	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,237 associations by consensus.

PROX1 vs HES6 — LUNG_SCLC

Explore this scatter interactively →