PROX1

Across TCGA cell cohorts, PROX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,728 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PROX1-associated GO terms across cancer lineages are Endocardium formation, Ventricular cardiac muscle cell development, and Regulation of forebrain neuron differentiation. Each is linked with PROX1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PROX1-to-partner and partner-to-PROX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endocardium formation grouped by PROX1-low versus PROX1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX1→partner) and Y-score (partner→PROX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Endocardium formation →	+1.458	+2.885	<.001	<.001	3	10
STOMACH	Ventricular cardiac muscle cell development →	-0.361	-3.017	<.001	<.001	3	9
SOFT_TISSUE	Regulation of forebrain neuron differentiation →	-0.242	-2.012	<.001	<.001	3	8
SOFT_TISSUE	Ventricular cardiac muscle cell differentiation →	-0.235	-1.929	<.001	<.001	3	8
LIVER	Cerebellar granular layer formation →	+1.370	+2.620	.002	.005	3	7
LIVER	Cerebellar granule cell differentiation →	+1.370	+2.620	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,728 associations by consensus.

Endocardium formation by PROX1 expression — LUNG_SCLC

Explore this box plot interactively →