PROX1

Across TCGA cell cohorts, PROX1 mutation is significantly associated with the RNA expression of many other genes, with 84 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PROX1-associated genes across cancer lineages are C2orf66, KRTAP6-1, and CCT8L2. Each is linked with PROX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROX1-to-partner and partner-to-PROX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf66 grouped by PROX1-low versus PROX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROX1→partner) and Y-score (partner→PROX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C2orf66 →	+0.183	+2.504	<.001	.009	3	2
SKIN	KRTAP6-1 →	+0.050	+4.022	<.001	.006	3	2
SKIN	CCT8L2 →	+0.043	+4.022	<.001	.006	3	2
BLOOD_Leukemia	CYP2C19 →	+0.023	+3.567	<.001	.003	3	2
URINARY_TRACT	DPPA5 →	+0.033	+5.087	<.001	.004	3	1
URINARY_TRACT	TXNDC8 →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

C2orf66 by PROX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →