PROX1-AS1

Across TCGA pan-cancer cohorts, PROX1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PROX1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PROX1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROX1-AS1 expression acts as an unfavorable survival marker, although some lineages such as OV and LGG show a favorable association.

KIRC, KIRP, and ACC are the cancer types where PROX1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.512	0.685	<.001	166	view →
KIRP	OS	Median	All	0.479	0.753	<.001	78	view →
ACC	DFS	Tertile	All	0.238	0.706	<.001	45	view →
OV	DFS	Tertile	III,IV	0.435	0.330	.010	42	view →
READ	DFS	Median	IV	0.179	0.936	.010	24	view →
KICH	DFS	Quartile	III,IV	0.155	1.000	.005	21	view →
BLCA	OS	Median	IV	0.256	0.542	.009	18	view →
LGG	DFS	Tertile	All	0.460	0.275	.005	16	view →
LAML	DFS	Median	All	0.688	0.500	.015	16	view →
PAAD	DFS	Tertile	All	0.476	0.221	.010	12	view →
LUSC	DFS	Median	III,IV	0.434	0.640	.018	10	view →
SKCM	OS	Tertile	All	0.382	0.259	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PROX1-AS1–KIRC (DFS)

Open the KIRC breakdown →