PROX1-AS1

Across TCGA pan-cancer cohorts, PROX1-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PROX1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PROX1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PROX1-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where PROX1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROX1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.958	<.001	11	view →
KIRC	Male	II,III,IV	−0.582	<.001	11	view →
COAD	Male	II,III,IV	+0.426	<.001	10	view →
HNSC	All	II,III,IV	+0.064	.003	8	view →
KICH	Male	All	−0.849	<.001	7	view →
KIRP	All	All	−0.373	<.001	6	view →
BRCA	All	III,IV	−0.168	<.001	6	view →
STAD	All	All	+0.256	.006	4	view →
UCEC	All	III,IV	−0.107	.015	4	view →
LUSC	All	All	+0.180	.002	3	view →
BLCA	Male	IV	−0.107	.014	3	view →
CHOL	All	All	+1.256	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PROX1-AS1–THCA

Open the THCA breakdown →