PROSER3

Across TCGA pan-cancer cohorts, PROSER3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PROSER3 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PROSER3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROSER3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where PROSER3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.477	1.000	.011	14	view →
LSCC	DFS	Median	All	0.500	0.826	.011	2	view →
UCEC	DFS	Median	All	1.000	0.912	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PROSER3–HNSC (DFS)

Open the HNSC breakdown →