PROSER3

Across TCGA pan-cancer cohorts, PROSER3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PROSER3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PROSER3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PROSER3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, HNSC, and COAD are the cancer types where PROSER3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROSER3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.833	<.001	11	view →
HNSC	Male	All	+0.746	<.001	10	view →
COAD	Male	II,III,IV	+0.717	<.001	10	view →
LIHC	Female	II,III,IV	+0.821	<.001	9	view →
BLCA	All	All	+0.684	<.001	8	view →
KIRC	All	All	+0.331	<.001	7	view →
BRCA	All	III,IV	+0.600	<.001	6	view →
THCA	All	All	−0.364	.001	6	view →
CHOL	Male	All	+2.305	<.001	5	view →
STAD	All	II,III,IV	+0.826	<.001	5	view →
KICH	Female	All	−0.736	<.001	5	view →
LUSC	All	All	+0.541	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PROSER3–KIRP

Open the KIRP breakdown →