PROSER3

Across TCGA patient cohorts, PROSER3 mutation is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROSER3-associated genes across cancer lineages are MTND3P9, MIR147A, and MIR4674. Each is linked with PROSER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROSER3-to-partner and partner-to-PROSER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND3P9 grouped by PROSER3-low versus PROSER3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER3→partner) and Y-score (partner→PROSER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTND3P9 →	+0.159	+4.070	.001	.009	3	3
BLCA	MIR147A →	+0.574	+5.588	<.001	.004	3	2
UCEC	MIR4674 →	+0.145	+2.451	.006	.007	3	2
CESC	RNU1-62P →	+0.174	+4.539	<.001	.008	3	2
CESC	RN7SKP77 →	+0.102	+5.837	<.001	.001	3	2
LUSC	UBL5P1 →	+0.234	+5.548	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

MTND3P9 by PROSER3 expression — COAD

Explore this box plot interactively →