PROSER3

Across TCGA patient cohorts, PROSER3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROSER3-associated genes across cancer lineages are RAD51, TSC1, and ERK2. Each is linked with PROSER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROSER3-to-partner and partner-to-PROSER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by PROSER3-low versus PROSER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER3→partner) and Y-score (partner→PROSER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.156	+3.459	.008	.005	3	2
UCEC	TSC1 →	-0.215	-2.222	.003	.011	3	2
UCEC	ERK2 →	+0.197	+3.169	.015	.018	3	1
UCEC	JNK2 →	+0.201	+2.331	.017	.019	3	1
UCEC	Annexin-1 →	+0.473	+3.019	.034	.019	3	1
UCEC	Shc_pY317 →	-0.186	-2.321	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

RAD51 by PROSER3 expression — UCEC

Explore this box plot interactively →