PROSER1

Across TCGA pan-cancer cohorts, PROSER1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PROSER1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PROSER1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PROSER1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where PROSER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.503	0.310	.012	6	view →
LSCC	OS	Quartile	II,III,IV	0.931	0.619	.020	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.431	0.788	.049	2	view →
UCEC	DFS	Tertile	All	0.951	0.800	.048	2	view →
LUAD	OS	Tertile	All	0.913	0.668	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PROSER1–PDAC (DFS)

Open the PDAC breakdown →