PROSER1

Across TCGA pan-cancer cohorts, PROSER1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PROSER1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PROSER1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PROSER1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, BLCA, and HNSC are the cancer types where PROSER1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROSER1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.294	<.001	11	view →
BLCA	All	III,IV	+0.960	<.001	10	view →
HNSC	Male	All	+0.749	<.001	10	view →
STAD	All	III,IV	+1.546	<.001	9	view →
THCA	All	All	−0.311	<.001	7	view →
UCEC	All	III,IV	+1.541	<.001	6	view →
LIHC	All	II,III,IV	+0.701	<.001	6	view →
BRCA	Female	II,III,IV	+0.410	<.001	6	view →
CHOL	Male	All	+2.343	<.001	5	view →
ESCA	All	All	+0.922	.001	5	view →
READ	Female	All	+1.503	.002	4	view →
LUSC	All	All	+0.241	.017	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PROSER1–COAD

Open the COAD breakdown →