PROSER1

Across TCGA patient cohorts, PROSER1 mutation is significantly associated with the RNA expression of many other genes, with 5,386 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROSER1-associated genes across cancer lineages are CCDC82, MTA2, and CPSF7. Each is linked with PROSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROSER1-to-partner and partner-to-PROSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC82 grouped by PROSER1-low versus PROSER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER1→partner) and Y-score (partner→PROSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC82 →	+0.336	+3.711	.008	<.001	3	2
UCEC	MTA2 →	+0.458	+2.435	<.001	<.001	3	2
UCEC	CPSF7 →	+0.400	+1.939	<.001	<.001	3	2
UCEC	SCLT1 →	+0.361	+1.730	<.001	<.001	3	2
UCEC	SUV39H2 →	+0.535	+2.408	<.001	<.001	3	2
UCEC	DCLRE1C →	+0.270	+3.042	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,386 associations by consensus.

CCDC82 by PROSER1 expression — UCEC

Explore this box plot interactively →