PROSER1

Across TCGA patient cohorts, PROSER1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROSER1-associated genes across cancer lineages are A-Raf_pS299, FASN, and MEK1. Each is linked with PROSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROSER1-to-partner and partner-to-PROSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PROSER1-low versus PROSER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER1→partner) and Y-score (partner→PROSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.124	-1.847	<.001	.007	3	2
UCEC	FASN →	+0.275	+1.353	.027	.015	3	2
UCEC	MEK1 →	+0.351	+2.070	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.120	-1.986	.010	.008	3	2
UCEC	Bak →	+0.181	+1.584	.021	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.562	+3.906	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

A-Raf_pS299 by PROSER1 expression — UCEC

Explore this box plot interactively →