PROSER1

Across TCGA cell cohorts, PROSER1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROSER1-associated genes across cancer lineages are PLA2G3, ALDOB, and AHCYL2. Each is linked with PROSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROSER1-to-partner and partner-to-PROSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by PROSER1-low versus PROSER1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROSER1→partner) and Y-score (partner→PROSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.549	+3.347	<.001	.005	3	1
LARGE_INTESTINE	ALDOB →	+1.669	+3.266	<.001	.005	3	1
LARGE_INTESTINE	AHCYL2 →	+1.773	+3.067	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	CYB5D1 →	+1.128	+3.064	<.001	.009	3	1
LARGE_INTESTINE	EFHC2 →	+0.511	+3.748	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PLA2G3 by PROSER1 expression — LARGE_INTESTINE

Explore this box plot interactively →