PRORP

Across TCGA patient cohorts, PRORP mutation is significantly associated with the RNA expression of many other genes, with 1,702 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRORP-associated genes across cancer lineages are LINC02647, RNA5SP158, and MIR153-1. Each is linked with PRORP in more than 2 cancer types. Because this analysis shows association rather than direction, both PRORP-to-partner and partner-to-PRORP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02647 grouped by PRORP-low versus PRORP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRORP→partner) and Y-score (partner→PRORP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02647 →	+0.294	+7.640	<.001	.009	3	3
HNSC	RNA5SP158 →	+0.326	+5.221	<.001	.003	3	2
LUAD	MIR153-1 →	+0.676	+5.157	<.001	.007	3	2
LUAD	MIR1302-5 →	+0.431	+5.044	<.001	.009	3	2
UCEC	CRYBB2P1 →	+0.410	+2.108	.008	.003	3	2
UCEC	NDUFAF5 →	+0.383	+2.162	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,702 associations by consensus.

LINC02647 by PRORP expression — BLCA

Explore this box plot interactively →