PROP1

Across TCGA patient cohorts, PROP1 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROP1-associated genes across cancer lineages are MIR6130, RNF166, and KCNG1. Each is linked with PROP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROP1-to-partner and partner-to-PROP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6130 grouped by PROP1-low versus PROP1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROP1→partner) and Y-score (partner→PROP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6130 →	+0.333	+8.471	<.001	.005	3	1
UCEC	RNF166 →	+0.443	+3.480	.006	.002	3	1
UCEC	KCNG1 →	-1.401	-3.459	.001	.005	3	1
UCEC	ACAP1 →	+0.618	+3.330	.003	.005	3	1
UCEC	MKNK2 →	+0.672	+3.470	.003	.003	3	1
CESC	LINC01953 →	+0.084	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

MIR6130 by PROP1 expression — BRCA

Explore this box plot interactively →