PROP1

Across TCGA pan-cancer cohorts, PROP1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PROP1 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PROP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PROP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

KIRC, TGCT, and UCS are the cancer types where PROP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	All	0.529	0.671	.004	58	view →
TGCT	OS	Tertile	II,III,IV	0.670	1.000	.005	36	view →
UCS	OS	Median	IV	0.255	0.752	.001	36	view →
OV	OS	Tertile	IV	0.602	0.824	.011	24	view →
HNSC	OS	Quartile	All	0.817	0.727	.013	20	view →
DLBC	OS	Tertile	IV	0.414	1.000	.010	19	view →
COAD	DFS	Tertile	II,III,IV	0.943	0.616	.016	18	view →
THCA	OS	Tertile	III,IV	0.929	0.985	.007	12	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.593	.015	10	view →
ACC	DFS	Tertile	IV	0.921	0.271	.016	9	view →
PAAD	DFS	Quartile	II,III,IV	0.275	0.494	.004	9	view →
ESCA	OS	Quartile	III,IV	0.677	0.369	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PROP1–KIRC (OS)

Open the KIRC breakdown →