PROP1

Across TCGA patient cohorts, PROP1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROP1-associated genes across cancer lineages are MSH2, JNK2, and 4E-BP1. Each is linked with PROP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROP1-to-partner and partner-to-PROP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PROP1-low versus PROP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROP1→partner) and Y-score (partner→PROP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.347	-2.990	.004	.036	3	1
UCEC	JNK2 →	+0.216	+3.321	.038	.010	1	1
UCEC	4E-BP1 →	+0.428	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MSH2 by PROP1 expression — UCEC

Explore this box plot interactively →