PROP1

Across TCGA cell cohorts, PROP1 RNA expression is significantly associated with the mutation status of many other genes, with 380 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROP1-associated genes across cancer lineages are C2CD3, AHNAK2, and PCDHGA2. Each is linked with PROP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROP1-to-partner and partner-to-PROP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2CD3 grouped by PROP1-low versus PROP1-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROP1→partner) and Y-score (partner→PROP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C2CD3 →	+4.906	+0.030	.006	<.001	3	3
BREAST	AHNAK2 →	+2.852	+0.062	.003	.008	3	3
BLOOD_Leukemia	PCDHGA2 →	+2.967	+0.017	.003	.001	3	3
OESOPHAGUS	DZANK1 →	+4.906	+0.030	.006	<.001	3	2
PANCREAS	TRPC3 →	+4.786	+0.019	.001	<.001	3	2
CNS	CUL7 →	+3.643	+0.029	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 380 associations by consensus.

C2CD3 by PROP1 expression — OESOPHAGUS

Explore this box plot interactively →