PROM2

Across TCGA patient cohorts, PROM2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROM2-associated genes across cancer lineages are p62 Lck ligand, ATM, and 4E-BP1. Each is linked with PROM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROM2-to-partner and partner-to-PROM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PROM2-low versus PROM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROM2→partner) and Y-score (partner→PROM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.373	+2.817	.002	.001	3	3
UCEC	ATM →	-0.581	-1.765	<.001	.014	3	3
UCEC	4E-BP1 →	+0.440	+2.936	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.229	-1.765	.015	.014	3	2
UCEC	JNK_pT183_Y185 →	-0.180	-1.752	.004	.014	3	2
UCEC	Notch1 →	+0.139	+2.009	.008	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

p62 Lck ligand by PROM2 expression — UCEC

Explore this box plot interactively →