PROM2

Across TCGA pan-cancer cohorts, PROM2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PROM2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PROM2 RNA is repressed in tumor relative to normal tissue. In most cancer types PROM2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where PROM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−5.264	<.001	12	view →
KIRP	Male	II,III,IV	−5.641	<.001	11	view →
COAD	Male	All	−1.785	<.001	11	view →
KICH	Male	II,III,IV	−3.293	<.001	9	view →
LUAD	Female	III,IV	+3.036	<.001	9	view →
LUSC	All	III,IV	+3.008	<.001	9	view →
BRCA	All	II,III,IV	+1.256	<.001	6	view →
CHOL	Male	All	+4.756	<.001	4	view →
LIHC	Male	III,IV	−0.386	<.001	3	view →
PAAD	All	All	+3.182	.022	2	view →
UCEC	All	All	+1.940	<.001	2	view →
READ	All	All	−1.653	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PROM2–KIRC

Open the KIRC breakdown →