PROM2

Across TCGA cell cohorts, PROM2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PROM2-associated genes across cancer lineages are CD40LG, PRAMEF25, and IL10. Each is linked with PROM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROM2-to-partner and partner-to-PROM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD40LG grouped by PROM2-low versus PROM2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROM2→partner) and Y-score (partner→PROM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CD40LG →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	PRAMEF25 →	+0.010	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUAD	IL10 →	+0.150	+3.067	<.001	.005	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.074	+3.944	<.001	.006	3	1
BREAST	FHL5 →	+0.094	+5.312	<.001	<.001	3	1
BREAST	ITGAD →	+0.120	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CD40LG by PROM2 expression — URINARY_TRACT

Explore this box plot interactively →