PROM1

Across TCGA pan-cancer cohorts, PROM1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PROM1 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PROM1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PROM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

COAD, UCEC, and OV are the cancer types where PROM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.144	0.704	<.001	18	view →
UCEC	DFS	Median	All	0.968	0.829	.024	8	view →
OV	OS	Median	III,IV	1.000	0.310	.036	6	view →
SARC	DFS	Median	All	0.094	0.591	.004	6	view →
LGG	OS	Median	All	0.195	0.889	<.001	6	view →
LIHC	OS	Median	All	0.505	0.777	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PROM1–COAD (DFS)

Open the COAD breakdown →