PROM1

Across TCGA pan-cancer cohorts, PROM1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PROM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PROM1 RNA is repressed in tumor relative to normal tissue. In most cancer types PROM1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where PROM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−3.866	<.001	12	view →
KICH	Female	II,III,IV	−5.638	<.001	11	view →
THCA	Male	All	−1.978	<.001	9	view →
BRCA	All	III,IV	−2.143	<.001	8	view →
UCEC	All	All	+1.993	<.001	6	view →
KIRP	All	III,IV	−1.950	.004	5	view →
HNSC	All	II,III,IV	−1.606	<.001	5	view →
LIHC	Male	III,IV	−0.994	<.001	5	view →
BLCA	All	All	−1.106	.007	4	view →
CHOL	Male	All	+3.830	<.001	2	view →
ESCA	All	II,III,IV	+3.589	.018	2	view →
STAD	Male	All	+1.545	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PROM1–KIRC

Open the KIRC breakdown →