PROM1

Across TCGA pan-cancer cohorts, PROM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PROM1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PROM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PROM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, UCEC, and GBM are the cancer types where PROM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.892	0.609	.001	21	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	8	view →
GBM	OS	Median	All	0.923	0.614	.009	4	view →
PDAC	OS	Tertile	III,IV	0.221	0.820	.035	4	view →
HNSC	DFS	Tertile	II,III,IV	0.764	0.533	.041	1	view →
LSCC	DFS	Median	All	0.848	1.000	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PROM1–CCRCC (DFS)

Open the CCRCC breakdown →