PROM1

Across TCGA patient cohorts, PROM1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROM1-associated genes across cancer lineages are Notch1, TFRC, and Caspase-7-cleavedD198. Each is linked with PROM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROM1-to-partner and partner-to-PROM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PROM1-low versus PROM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROM1→partner) and Y-score (partner→PROM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+2.128	<.001	.009	3	2
UCEC	TFRC →	+0.596	+2.087	.003	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.932	+2.341	<.001	.003	3	2
UCEC	c-Jun_pS73 →	-0.148	-2.087	.014	.005	3	2
UCEC	4E-BP1 →	+0.359	+2.029	<.001	.017	3	2
COAD	TIGAR →	+0.486	+2.815	.025	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Notch1 by PROM1 expression — UCEC

Explore this box plot interactively →