PROM1

Across TCGA cell cohorts, PROM1 mutation is significantly associated with the RNA expression of many other genes, with 1,214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROM1-associated genes across cancer lineages are IL22, SLC6A18, and OR4S1. Each is linked with PROM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROM1-to-partner and partner-to-PROM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by PROM1-low versus PROM1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROM1→partner) and Y-score (partner→PROM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL22 →	+0.075	+4.029	<.001	.009	3	2
OVARY	SLC6A18 →	+0.051	+4.990	<.001	.001	3	2
LUNG_SCLC	OR4S1 →	+0.026	+5.643	<.001	.002	3	1
LUNG_SCLC	CLEC4C →	+0.047	+5.029	<.001	.006	3	1
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1
STOMACH	TSBP1 →	+0.054	+4.794	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,214 associations by consensus.

IL22 by PROM1 expression — OVARY

Explore this box plot interactively →