PROKR2

Across TCGA cell cohorts, PROKR2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PROKR2-associated genes across cancer lineages are TBC1D3, SPZ1, and RNASE3. Each is linked with PROKR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROKR2-to-partner and partner-to-PROKR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by PROKR2-low versus PROKR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROKR2→partner) and Y-score (partner→PROKR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.043	+2.688	.007	.008	3	1
CNS	SPZ1 →	+0.024	+3.584	<.001	.003	3	1
CNS	RNASE3 →	+0.065	+3.584	<.001	.003	3	1
CNS	CDY2A →	+0.004	+4.321	.002	<.001	3	1
STOMACH	KRTAP19-7 →	+0.047	+4.285	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.022	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TBC1D3 by PROKR2 expression — LARGE_INTESTINE

Explore this box plot interactively →