PROKR1

Across TCGA patient cohorts, PROKR1 mutation is significantly associated with the RNA expression of many other genes, with 3,655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROKR1-associated genes across cancer lineages are FEN1, TYMS, and TYMSOS. Each is linked with PROKR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PROKR1-to-partner and partner-to-PROKR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEN1 grouped by PROKR1-low versus PROKR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROKR1→partner) and Y-score (partner→PROKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.715	+2.906	<.001	.001	3	3
UCEC	TYMS →	+0.840	+2.807	<.001	<.001	3	3
UCEC	TYMSOS →	+0.677	+2.595	<.001	.005	3	3
UCEC	RAD51 →	+0.732	+2.332	<.001	<.001	3	3
UCEC	KIF22 →	+0.463	+2.839	.003	.001	3	3
SKCM	TEDC1 →	+0.503	+3.350	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,655 associations by consensus.

FEN1 by PROKR1 expression — UCEC

Explore this box plot interactively →