PROCA1

Across TCGA patient cohorts, PROCA1 mutation is significantly associated with the RNA expression of many other genes, with 687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROCA1-associated genes across cancer lineages are RPL35AP30, RN7SL861P, and RN7SL359P. Each is linked with PROCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROCA1-to-partner and partner-to-PROCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL35AP30 grouped by PROCA1-low versus PROCA1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROCA1→partner) and Y-score (partner→PROCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL35AP30 →	+0.215	+4.421	.001	.009	3	2
READ	RN7SL861P →	+0.360	+4.724	<.001	.003	3	2
READ	RN7SL359P →	+0.283	+4.361	.003	.006	3	2
READ	CXCL1P1 →	+0.318	+4.421	<.001	.009	3	2
COAD	MAPK6P4 →	+0.096	+3.160	<.001	.003	3	2
COAD	GAPDHP17 →	+0.060	+4.136	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 687 associations by consensus.

RPL35AP30 by PROCA1 expression — READ

Explore this box plot interactively →