PROC

Across TCGA pan-cancer cohorts, PROC Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PROC data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PROC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PROC expression acts as an unfavorable survival marker.

OV, BRCA, and KIRC are the cancer types where PROC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.082	0.844	<.001	36	view →
BRCA	OS	Median	All	0.165	0.924	<.001	36	view →
KIRC	OS	Median	All	0.214	0.630	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PROC–OV (OS)

Open the OV breakdown →