PROC

Across TCGA pan-cancer cohorts, PROC RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PROC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PROC RNA is repressed in tumor relative to normal tissue. In most cancer types PROC is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and HNSC are the cancer types where PROC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PROC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−3.736	<.001	11	view →
KIRC	Male	III,IV	−1.742	<.001	11	view →
HNSC	Male	III,IV	+1.266	<.001	11	view →
LUAD	Male	II,III,IV	+1.089	<.001	11	view →
THCA	All	II,III,IV	+0.907	<.001	9	view →
KIRP	All	III,IV	−2.573	<.001	8	view →
BLCA	All	III,IV	+1.200	.002	7	view →
LUSC	All	All	+0.717	<.001	6	view →
BRCA	All	All	+0.674	<.001	6	view →
PAAD	All	All	+1.479	.020	4	view →
STAD	Male	II,III,IV	+1.374	<.001	4	view →
UCEC	All	III,IV	+0.421	.033	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PROC–KICH

Open the KICH breakdown →