PROC

Across TCGA pan-cancer cohorts, PROC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PROC data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PROC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PROC expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUAD, GBM, and UCEC are the cancer types where PROC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.312	0.869	.004	25	view →
GBM	OS	Quartile	All	1.000	0.684	.005	19	view →
UCEC	DFS	Median	III,IV	0.499	0.880	.036	12	view →
LSCC	DFS	Median	II,III,IV	0.836	1.000	.005	8	view →
PDAC	OS	Quartile	III,IV	0.500	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PROC–LUAD (OS)

Open the LUAD breakdown →