PROC

Across TCGA patient cohorts, PROC protein abundance is significantly associated with the RNA expression of many other genes, with 9,328 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PROC-associated genes across cancer lineages are SERPINE1, FOSB, and LYVE1. Each is linked with PROC in more than 8 cancer types. Because this analysis shows association rather than direction, both PROC-to-partner and partner-to-PROC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PROC versus SERPINE1 in OV, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROC→partner) and Y-score (partner→PROC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINE1 →	+1.851	+0.662	<.001	<.001	3	9
CCRCC	FOSB →	+1.923	+0.455	<.001	.001	3	8
BRCA	LYVE1 →	+1.621	+0.689	<.001	<.001	3	8
OV	VEGFC →	+0.882	+0.655	<.001	<.001	3	7
CCRCC	TMEM88 →	+0.872	+0.399	<.001	<.001	3	7
CCRCC	MYCT1 →	+0.912	+0.466	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,328 associations by consensus.

PROC vs SERPINE1 — OV

Explore this scatter interactively →