PROC

Across TCGA cell cohorts, PROC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,300 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PROC-associated GO terms across cancer lineages are Intrinsic apoptotic signaling pathway, Regulation of protein localization to nucleus, and Negative regulation of calcium ion export across plasma membrane. Each is linked with PROC in more than 8 cancer types. Because this analysis shows association rather than direction, both PROC-to-partner and partner-to-PROC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intrinsic apoptotic signaling pathway grouped by PROC-low versus PROC-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PROC→partner) and Y-score (partner→PROC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Intrinsic apoptotic signaling pathway →	+0.053	+0.922	.005	.004	3	9
BREAST	Regulation of protein localization to nucleus →	+0.080	+0.655	.001	.002	3	9
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.089	+0.757	.002	.001	3	9
BONE	Negative regulation of RNA splicing →	+0.102	+0.855	.001	.004	3	9
OVARY	Positive regulation of stem cell population maintenance →	+0.063	+0.905	.002	.003	3	9
BREAST	Regulation of alternative mRNA splicing, via spliceosome →	+0.117	+1.099	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,300 associations by consensus.

Intrinsic apoptotic signaling pathway by PROC expression — PANCREAS

Explore this box plot interactively →