PROC

Across TCGA cell cohorts, PROC mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PROC-associated genes across cancer lineages are TRIM43B, PGLYRP3, and MAGEB4. Each is linked with PROC in more than 1 cancer types. Because this analysis shows association rather than direction, both PROC-to-partner and partner-to-PROC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM43B grouped by PROC-low versus PROC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROC→partner) and Y-score (partner→PROC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIM43B →	+0.025	+3.857	.004	.006	3	1
LUNG_NSCLC_LUAD	PGLYRP3 →	+0.166	+3.866	.006	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	CSN1S1 →	+0.059	+3.669	<.001	<.001	3	1
LARGE_INTESTINE	STAC2 →	+0.159	+2.878	.001	.009	3	1
LARGE_INTESTINE	STRA8 →	+0.101	+4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TRIM43B by PROC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →