Across TCGA patient cohorts, PROB1 mutation is significantly associated with the RNA expression of many other genes, with 868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PROB1-associated genes across cancer lineages are RN7SKP214, TRGJP1, and OR10G6. Each is linked with PROB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PROB1-to-partner and partner-to-PROB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PROB1→partner) and Y-score (partner→PROB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP214 →	+0.181	+1.804	.001	.004	3	2
UCEC	TRGJP1 →	+0.426	+1.969	<.001	.008	3	2
COAD	OR10G6 →	+0.204	+4.308	<.001	.009	3	1
COAD	RNU6-666P →	+0.787	+6.149	<.001	<.001	3	1
COAD	SNORD114-28 →	+0.603	+5.136	<.001	.002	3	1
COAD	RNU6-414P →	+0.943	+3.754	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 868 associations by consensus.

Exploration

PROB1 survival (RNA) · tumor vs normal (RNA) · all PROB1 data types