PRNT

Across TCGA patient cohorts, PRNT mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRNT-associated genes across cancer lineages are P-Cadherin, Chk2_pT68, and Di-Ras3. Each is linked with PRNT in more than 1 cancer types. Because this analysis shows association rather than direction, both PRNT-to-partner and partner-to-PRNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by PRNT-low versus PRNT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRNT→partner) and Y-score (partner→PRNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	P-Cadherin →	-0.201	-2.990	.011	.036	2	1
UCEC	Chk2_pT68 →	-0.214	-2.990	.036	.036	2	1
UCEC	Di-Ras3 →	-0.207	-3.169	.011	.020	2	1
UCEC	4E-BP1 →	+0.307	+3.169	.038	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

P-Cadherin by PRNT expression — UCEC

Explore this box plot interactively →